Edinburgh Research Explorer

Promotion of avian endothelial cell differentiation by GATA transcription factors

Research output: Contribution to journalArticle

  • Caramai N Kamei
  • Hervé Kempf
  • Ronit Yelin
  • Georges Daoud
  • Richard G James
  • Andrew B Lassar
  • Clifford J Tabin
  • Thomas M Schultheiss

Related Edinburgh Organisations

Open Access permissions

Open

Documents

  • Download as Adobe PDF

    Rights statement: Freely available in PMC.

    Accepted author manuscript, 2 MB, PDF document

Original languageEnglish
Pages (from-to)29-37
Number of pages9
JournalDevelopmental Biology
Volume353
Issue number1
DOIs
Publication statusPublished - 1 May 2011

Abstract

In the avian embryo, endothelial cells originate from several sources, including the lateral plate and somite mesoderm. In this study, we show that Gata transcription factors are expressed in the lateral plate and in vasculogenic regions of the avian somite and are able to promote a vascular endothelial fate when ectopically expressed in somite precursors. A fusion of GATA4 to the transcriptional activator VP16 promoted endothelium formation, indicating that GATA transcription factors promote vasculogenesis via activation of downstream targets, while a fusion of GATA4 to the transcriptional repressor engrailed repressed expression of Vascular Endothelial Growth Factor Receptor 2, a marker of endothelial precursors. These findings indicate a role for GATA transcription factors in the differentiation of the endothelium.

    Research areas

  • Animals, Apoptosis, Avian Proteins, Bone Morphogenetic Protein 2, Cell Differentiation, Chick Embryo, Coturnix, Endothelial Cells, GATA Transcription Factors, Mesoderm

Download statistics

No data available

ID: 13087489