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P-selectin antagonism reduces thrombus formation in humans

Research output: Contribution to journalArticle

  • R Chelliah
  • A J Lucking
  • L Tattersall
  • S Daga
  • N J Beresford-Cleary
  • K Cortas
  • K A A Fox
  • G Z Feuerstein
  • T M Connolly
  • D E Newby

Related Edinburgh Organisations

Original languageEnglish
Pages (from-to)1915-9
Number of pages5
JournalJournal of Thrombosis and Haemostasis
Volume7
Issue number11
DOIs
Publication statusPublished - Nov 2009

Abstract

Interaction of P-selectin with its glycoprotein ligand (P-selectin glycoprotein ligand type 1) mediates inflammatory processes that may also include vascular thrombosis. Platelet P-selectin expression is increased in patients with coronary heart disease, and its antagonism represents a potential future therapeutic target for the prevention and treatment of atherothrombosis.

ID: 2504801