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Recombinant tissue plasminogen activator for acute ischaemic stroke: an updated systematic review and meta-analysis

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    Rights statement: Copyright © 2012 Elsevier Ltd. All rights reserved. This document may be redistributed and reused, subject to certain conditions.

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Original languageEnglish
Pages (from-to)2364-72
Number of pages9
JournalThe Lancet
Issue number9834
Publication statusPublished - 2012


Recombinant tissue plasminogen activator (rt-PA, alteplase) improved functional outcome in patients treated soon after acute ischaemic stroke in randomised trials, but licensing is restrictive and use varies widely. The IST-3 trial adds substantial new data. We therefore assessed all the evidence from randomised trials for rt-PA in acute ischaemic stroke in an updated systematic review and meta-analysis.

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