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Recommendations for Minimum Information for Publication of Experimental Pathology Data: MINPEPA Guidelines

Research output: Contribution to journalLiterature review

  • C Scudamore (Invited Reviewer)
  • Elizabeth J Soilleux (Invited Reviewer)
  • Natasha A Karp (Invited Reviewer)
  • Ken Smith (Invited Reviewer)
  • Richard Poulsom (Invited Reviewer)
  • Charles Herrington (Invited Reviewer)
  • Michael Day (Invited Reviewer)
  • Cory Brayton (Invited Reviewer)
  • Brad Bolon (Invited Reviewer)
  • Christopher Whitelaw (Invited Reviewer)
  • Eric White (Invited Reviewer)
  • Jeffrey Everitt (Invited Reviewer)
  • Mark Arends (Invited Reviewer)

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    Rights statement: This is the peer reviewed version of the following article, which has been published in final form at http://onlinelibrary.wiley.com/doi/10.1002/path.4642/abstract. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving

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    Licence: Creative Commons: Attribution Non-Commercial (CC-BY-NC)

http://onlinelibrary.wiley.com/doi/10.1002/path.4642/abstract
Original languageEnglish
Pages (from-to)359-367
JournalThe Journal of Pathology
Volume238
Issue number2
Early online date21 Sep 2015
DOIs
Publication statusPublished - Jan 2016

Abstract

Animal models are essential research tools in modern biomedical research, but there are concerns about their lack of reproducibility and the failure of animal data to translate into advances in human medical therapy. A major factor in improving experimental reproducibility is thorough communication of research methodologies. The recently published ARRIVE guidelines outline basic information that should be provided when reporting animal studies. This paper builds on ARRIVE by providing the minimum information needed in reports to allow proper assessment of pathology data gathered from animal tissues. This guidance covers aspects of experimental design, technical procedures, data gathering, analysis and presentation that are potential sources of variation when creating morphological, immunohistochemical (IHC) or in situ hybridisation (ISH) datasets. This reporting framework will maximise the likelihood that pathology data derived from animal experiments can be reproduced by ensuring that sufficient information is available to allow for replication of the methods and facilitate inter-study comparison by identifying potential interpretative confounders.

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