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Regional localization of the murine Duchenne muscular dystrophy gene on the mouse X chromosome

Research output: Contribution to journalArticle

  • J S Chamberlain
  • S G Grant
  • A A Reeves
  • L J Mullins
  • D A Stephenson
  • E P Hoffman
  • A P Monaco
  • L M Kunkel
  • C T Caskey
  • V M Chapman

Related Edinburgh Organisations

Original languageEnglish
Pages (from-to)671-8
Number of pages8
JournalSomatic Cell and Molecular Genetics
Volume13
Issue number6
Publication statusPublished - Nov 1987

Abstract

The murine locus corresponding to the human Duchenne/Becker muscular dystrophy (DMD) gene has been regionally mapped on the mouse X chromosome by hybridizing DNA from interspecies mouse crosses with a cDNA clone for the mouse Dmd gene. The results demonstrate that the relative organization of genes on the murine and human X chromosomes is more divergent than has previously been postulated. Furthermore, the mouse Dmd gene maps to a similar region of the X chromosome as does the mouse muscular dystrophy mutation mdx, providing further evidence that the mdx mutant may be a murine equivalent of human DMD. However, Southern analysis of portions of the mouse Dmd gene has not yet revealed any differences between mdx and wild-type mice.

    Research areas

  • Animals, Chromosome Mapping, DNA, Disease Models, Animal, Genetic Linkage, Humans, Mice, Muscular Dystrophy, Animal, Mutation, Nucleic Acid Hybridization, Polymorphism, Restriction Fragment Length, Species Specificity, X Chromosome

ID: 19417090