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Repo-Man-PP1: A link between chromatin remodelling and nuclear envelope reassembly

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Original languageEnglish
Pages (from-to)138 - 142
JournalNucleus (Austin, Tex.)
Volume3
Issue number2
DOIs
Publication statusPublished - 1 Mar 2012

Abstract

Coordination of late mitotic events is crucial for the maintenance of genome stability and for the control of gene expression after cell division. Reversible protein phosphorylation regulates this process by de-phosphorylation of mitotic phospho-proteins in a sequential and coordinated manner: this allows an orderly sequence of events to take place during mitotic exit. We have identified Repo-Man/PP1 as a phosphatase complex that regulates temporally and spatially chromatin re-organization and nuclear envelope re-formation during anaphase-telophase.

    Research areas

  • Nup 153, Protein Phosphatase 1, Repo-Man, importin beta, mitotic exit

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