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Resident cells of the myocardium:more than spectators in cardiac injury, repair and regeneration

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Original languageEnglish
Pages (from-to)46-51
Number of pages6
JournalCurrent opinion in physiology
Volume1
Early online date13 Dec 2017
DOIs
Publication statusPublished - Feb 2018

Abstract

Multiple resident cell types contribute to maintaining the structure and physiological function of the heart over the life course. Cardiomyocyte proliferation supports scar free regeneration in the neonatal heart following injury, but a lower rate of proliferation in the adult necessitates replacement by a collagen scar to maintain ventricular integrity. In this short review we discuss recent studies that have identified novel roles for non-myocyte resident cells and the extracellular matrix in supporting repair, as well as cardiomyocyte and vascular regeneration, following myocardial infarction.

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