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Responsive Polymeric Nanoparticles for Controlled Drug Delivery

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http://doi.wiley.com/10.1002/pi.5471
Original languageEnglish
JournalPolymer International
Early online date11 Sep 2017
DOIs
Publication statusE-pub ahead of print - 11 Sep 2017

Abstract

Small molecule drugs often have limited solubility or display rapid clearance showing poor selectivity that leads to undesired side-effects. Although prodrug strategies can improve solubility and lower toxicity, activation “on demand” as well as targeted transport of prodrugs remains a challenge in drug delivery. Responsive polymeric nanoparticles can help obliterate these challenges with the encapsulation or conjugation of drugs, allowing release at the target site upon triggering by an internal or external stimulus. The adaptable design of polymeric nanoparticles allows them to play a vital role in achieving the specific and desired response following application of a specific stimulus. Here, the most recent progress in responsive polymeric nanoparticles is reviewed with a focus on the chemical properties of the utilised polymers.

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