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Risk of Bias in Reports of In Vivo Research: A Focus for Improvement

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    Rights statement: Copyright: © 2015 Macleod et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

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http://dx.plos.org/10.1371/journal.pbio.1002273
Original languageEnglish
Pages (from-to)e1002273
JournalPLoS Biology
Volume13
Issue number10
DOIs
Publication statusPublished - 13 Oct 2015

Abstract

The reliability of experimental findings depends on the rigour of experimental design. Here we show limited reporting of measures to reduce the risk of bias in a random sample of life sciences publications, significantly lower reporting of randomisation in work published in journals of high impact, and very limited reporting of measures to reduce the risk of bias in publications from leading United Kingdom institutions. Ascertainment of differences between institutions might serve both as a measure of research quality and as a tool for institutional efforts to improve research quality.

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