Edinburgh Research Explorer

Risk-averse personalities have a systemically potentiated neuroendocrine stress axis: a multilevel experiment in Parus major

Research output: Contribution to journalArticle

  • Alexander T Baugh
  • Rebecca A Senft
  • Marian Firke
  • Alexander Lauder
  • Julia Schroeder
  • Simone Meddle
  • Kees van Oers
  • Michaela Hau

Related Edinburgh Organisations

Open Access permissions



  • Download as Adobe PDF

    Final published version, 555 KB, PDF document

    Licence: Creative Commons: Attribution (CC-BY)

Original languageEnglish
Pages (from-to)99-108
JournalHormones and Behavior
Early online date26 May 2017
Publication statusPublished - Jul 2017


Hormonal pleiotropy—the simultaneous influence of a single hormone on multiple traits—has been hypothesized as an important mechanism underlying personality, and circulating glucocorticoids are central to this idea. A major gap in our understanding is the neural basis for this link. Here we examine the stability and structure of behavioral, endocrine and neuroendocrine traits in a population of songbirds (Parus major). Upon identifying stable and covarying behavioral and endocrine traits, we test the hypothesis that risk-averse personalities exhibit a neuroendocrine stress axis that is systemically potentiated—characterized by stronger glucocorticoid reactivity and weaker negative feedback. We show high among-individual variation and covariation (i.e. personality) in risk-taking behaviors and demonstrate that four aspects of glucocorticoid physiology (baseline, stress response, negative feedback strength and adrenal sensitivity) are also repeatable and covary. Further, we establish that high expression of mineralocorticoid and low expression of glucocorticoid receptor in the brain are linked with systemically elevated plasma glucocorticoid levels and more risk-averse personalities. Our findings support the hypothesis that steroid hormones can exert pleiotropic effects that organize behavioral phenotypes and provide novel evidence that neuroendocrine factors robustly explain a large fraction of endocrine and personality variation.

Download statistics

No data available

ID: 30390335