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Scottish and Newcastle antiemetic pre-treatment for paracetamol poisoning study (SNAP)

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    Rights statement: © 2013 Thanacoody et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Original languageEnglish
Pages (from-to)20
JournalBMC Pharmacology and Toxicology
Publication statusPublished - 4 Apr 2013


Paracetamol (acetaminophen) poisoning remains the commonest cause of acute liver injury in Europe and North America. The intravenous (IV) N-acetylcysteine (NAC) regimen introduced in the 1970s has continued effectively unchanged. This involves 3 different infusion regimens (dose and time) lasting over 20 hours. The same weight-related dose of NAC is used irrespective of paracetamol dose. Complications include frequent nausea and vomiting, anaphylactoid reactions and dosing errors. We designed a randomised controlled study investigating the efficacy of antiemetic pre-treatment (ondansetron) using standard NAC and a modified, shorter, regimen.

    Research areas

  • Acetaminophen, Acetylcysteine, Anti-Inflammatory Agents, Non-Steroidal, Antiemetics, Double-Blind Method, Humans, Ondansetron, Scotland, Vomiting

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