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Screening of a Combinatorial Homing Peptide Library for Selective Cellular Delivery

Research output: Contribution to journalArticle

Original languageEnglish
Pages (from-to)6133-6136
Number of pages4
JournalAngewandte Chemie International Edition
Volume50
Issue number27
DOIs
Publication statusPublished - Jun 2011

Abstract

The identification of peptides to optimize both the delivery and tumor penetration of existing cancer drugs in a cell-selective manner would be highly desirable. The screening of a peptide nucleic acid (PNA)-encoded peptide library (see picture) now allows the identification of versatile cell homing peptides for any cell type of interest.

    Research areas

  • drug delivery, homing peptides, microarrays, peptide nucleic acids, peptides, PENETRATING-PEPTIDE, PHENOTYPIC HETEROGENEITY, FLOW-CYTOMETRY, DRUG-DELIVERY, TAT PEPTIDE, CELLS, LEUKEMIA, MOUSE, GENE, LINE

ID: 1477995