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Seminal plasma and prostaglandin E2 up-regulate fibroblast growth factor 2 expression in endometrial adenocarcinoma cells via E-series prostanoid-2 receptor-mediated transactivation of the epidermal growth factor receptor and extracellular signal-regulated kinase pathway

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    Rights statement: Published in final edited form as: Hum Reprod. 2007 January ; 22(1): 36–44. doi:10.1093/humrep/del328

    Accepted author manuscript, 1.2 MB, PDF document

Original languageEnglish
Pages (from-to)36-44
Number of pages9
JournalHuman Reproduction
Issue number1
Publication statusPublished - 2007


Prostaglandin E(2) (PGE(2)) has been shown to modulate angiogenesis and tumour progression via the E-series prostanoid-2 (EP2) receptor. Endometrial adenocarcinomas may be exposed to endogenous PGE(2) and exogenous PGE(2), present at high concentration in seminal plasma.

    Research areas

  • Endometrial carcinoma, E-series prostanoid receptor 2, Fibroblast Growth Factor 2, SEMINAL PLASMA

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