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Smooth muscle enriched long non-coding RNA (SMILR) regulates cell proliferation

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Original languageEnglish
JournalCirculation
Volume133
Issue number21
Early online date6 Apr 2016
DOIs
Publication statusPublished - 24 May 2016

Abstract

Background - Phenotypic switching of vascular smooth muscle cells (VSMCs) from a contractile to a synthetic state is implicated in diverse vascular pathologies including atherogenesis, plaque stabilisation, and neointimal hyperplasia. However, very little is known as to the role of long non coding RNA (lncRNA) during this process. Here we investigated a role for long non-coding (lnc)RNAs in VSMC biology and pathology.

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