Edinburgh Research Explorer

SNP based heritability estimates of common and specific variance in self and informant reported neuroticism scales

Research output: Contribution to journalArticle

  • Anu Realo
  • Peter J. Van Der Most
  • Jüri Allik
  • Tõnu Esko
  • Bertus F. Jeronimus
  • Liisi Kööts-ausmees
  • René Mõttus
  • Felix C. Tropf
  • Harold Snieder
  • Johan Ormel

Related Edinburgh Organisations

Open Access permissions

Open

Documents

  • Download as Adobe PDF

    Rights statement: This is the peer reviewed version of the following article: Realo, A., van der Most, P. J., Allik, J., Esko, T., Jeronimus, B. F., Kööts-Ausmees, L., Mõttus, R., Tropf, F. C., Snieder, H. and Ormel, J. (2017), SNP-Based Heritability Estimates of Common and Specific Variance in Self- and Informant-Reported Neuroticism Scales. J Pers. doi:10.1111/jopy.12297, which has been published in final form at doi:10.1111/jopy.12297. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.

    Accepted author manuscript, 802 KB, PDF document

Original languageEnglish
JournalJournal of Personality
Early online date13 Feb 2017
DOIs
Publication statusE-pub ahead of print - 13 Feb 2017

Abstract

Objective
Our study aims to estimate the proportion of the phenotypic variance of Neuroticism and its facet scales that can be attributed to common single-nucleotide polymorphisms (SNPs) in two adult populations from Estonia (EGCUT; N = 3,292) and the Netherlands (Lifelines; N = 13,383).

Method
Genomic-relatedness-matrix restricted maximum likelihood (GREML) using genome-wide complex trait analysis (GCTA) software was employed. To build upon previous research, we used self- and informant reports of the 30-facet NEO personality inventories and analyzed both the usual sum scores and the residual facet scores of Neuroticism.

Results
In the EGCUT cohort, the proportion of phenotypic variance explained by the additive effects of common genetic variants in self- and informant-reported Neuroticism domain scores was 15.2% (p = .070, SE = .11) and 6.2% (p = .293, SE = .12), respectively. The SNP-based heritability estimates at the level of Neuroticism facet scales differed greatly across cohorts and modes of measurement but were generally higher (a) for self- than for informant reports, and (b) for sum than for residual scores.

Conclusions
Our findings indicate that a large proportion of the heritability of Neuroticism is not captured by additive genetic effects of common SNPs, with some evidence for Gene × Environment interaction across cohorts.

    Research areas

  • neuroticism, GREML-GCTA, SNP-based heritability, self- versus informant reports, sum versus residual scores

Download statistics

No data available

ID: 31790900