TY - JOUR
T1 - Solvable senescence model with positive mutations
AU - Coe, J B
AU - Mao, Y
AU - Cates, M E
PY - 2004/8
Y1 - 2004/8
N2 - We build upon our previous analytical results for the Penna model of senescence to include positive mutations. We investigate whether a small but nonzero positive mutation rate gives qualitatively different results to the traditional Penna model in which no positive mutations are considered. We find that the high-lifespan tail of the distribution is radically changed in structure, but that there is not much effect on the bulk of the population. The mortality plateau that we found previously for a stochastic generalization of the Penna model is stable to a small positive mutation rate.
AB - We build upon our previous analytical results for the Penna model of senescence to include positive mutations. We investigate whether a small but nonzero positive mutation rate gives qualitatively different results to the traditional Penna model in which no positive mutations are considered. We find that the high-lifespan tail of the distribution is radically changed in structure, but that there is not much effect on the bulk of the population. The mortality plateau that we found previously for a stochastic generalization of the Penna model is stable to a small positive mutation rate.
U2 - 10.1103/PhysRevE.70.021907
DO - 10.1103/PhysRevE.70.021907
M3 - Article
VL - 70
SP - -
JO - Physical Review E - Statistical, Nonlinear and Soft Matter Physics
JF - Physical Review E - Statistical, Nonlinear and Soft Matter Physics
SN - 1539-3755
IS - 2
M1 - 021907
ER -