Edinburgh Research Explorer

Spreading depolarisations and outcome after traumatic brain injury: a prospective observational study

Research output: Contribution to journalArticle

  • Jed A Hartings
  • M Ross Bullock
  • David O Okonkwo
  • Lilian S Murray
  • Gordon D Murray
  • Martin Fabricius
  • Andrew Ir Maas
  • Johannes Woitzik
  • Oliver Sakowitz
  • Bruce Mathern
  • Bob Roozenbeek
  • Hester Lingsma
  • Jens P Dreier
  • Ava M Puccio
  • Lori A Shutter
  • Clemens Pahl
  • Anthony J Strong
  • Co-Operative Study on Brain Injury Depolarisations

Related Edinburgh Organisations

Original languageEnglish
Pages (from-to)1058-64
Number of pages7
JournalLancet Neurology
Issue number12
Publication statusPublished - 2011


Pathological waves of spreading mass neuronal depolarisation arise repeatedly in injured, but potentially salvageable, grey matter in 50-60% of patients after traumatic brain injury (TBI). We aimed to ascertain whether spreading depolarisations are independently associated with unfavourable neurological outcome.

ID: 3335271