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Strategies for the preparation of synthetic transfection vectors

Research output: Contribution to journalArticle

Original languageEnglish
Pages (from-to)15-49
Number of pages35
JournalTopics in Current Chemistry
Volume296
Publication statusPublished - 2010

Abstract

In the late 1980s independent work by Felgner and Behr pioneered the use of cationic materials to complex and deliver nucleic acids into eukaryotic cells. Since this time, a vast number of synthetic transfection vectors, which are typically divided into two main "transfectors", have been developed namely: (1) cationic lipids and (2) polycationic polymers. In this chapter the main synthetic approaches used for the synthesis of these compounds will be reviewed with particular attention paid to: cationic lipids and dendrimers. This review is aimed primarily at the younger audience of doctoral students and non-specialist readers.

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