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STROKOG (Stroke and Cognition consortium): An international consortium to examine the epidemiology, diagnosis and treatment of neurocognitive disorders in relation to cerebrovascular disease

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  • Perminder S Sachdev
  • Jessica W. Lo
  • John Crawford
  • Lisa Mellon
  • Anne Hickey
  • David Williams
  • Régis Bordet
  • Anne-Marie Mendyk
  • Patrick Gelé
  • Dominique Deplanque
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  • Yan-Hong Dong
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  • Louise M. Allan
  • Rufus O. Akinyemi
  • Adesola Ogunniyi
  • Aleksandra Klimkowicz-Mrowiec
  • Martin Dichgans
  • Frank A. Wollenweber
  • Vera Zietemann
  • Michael Hoffmann
  • David W. Desmond
  • Thomas Linden
  • Christian Blomstrand
  • Björn Fagerberg
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  • Olivier Godefroy
  • Mélanie Barbay
  • Martine Roussel
  • Byung-Chul Lee
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  • Amanda G Thrift
  • Geoffrey A Donnan
  • Naganedran Kandiah
  • Russell J. Chander
  • Xuling Lin
  • Charlotte Cordonnier
  • Solene Moulin
  • Costanza Rossi
  • Behnam Sabayan
  • David J. Stott
  • J. Wouter Jukema
  • Susanna Melkas
  • Hanna Jokinen
  • Timo Erkinjuntti
  • Vincent C.T. Mok
  • Adrian Wong
  • Bonnie Y.K. Lam
  • Didier Leys
  • Hilde Hénon
  • Stéphanie Bombois
  • Darren M. Lipnicki
  • Nicole A. Kochan

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Original languageEnglish
JournalAlzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
Early online date18 Nov 2016
Publication statusE-pub ahead of print - 18 Nov 2016


Background: The Stroke and Cognition consortium (STROKOG) aims to facilitate a better understanding of the determinants of vascular contributions to cognitive disorders and help improve the diagnosis and treatment of vascular cognitive disorders (VCD).
Methods: Longitudinal studies with ≥ 75 participants who had suffered or were at risk of stroke or TIA, and which evaluated cognitive function were invited to join STROKOG. The consortium will facilitate projects investigating rates and patterns of cognitive decline, risk factors for VCD, and biomarkers of vascular dementia.
Results: Currently STROKOG includes 25 (21 published) studies, with 12,092 participants from 5 continents. The duration of follow up ranges from 3 months to 21 years.
Discussion: While data harmonisation will be a key challenge, STROKOG is in a unique position to reuse and combine international cohort data and fully explore patient level characteristics and outcomes. STROKOG could potentially transform our understanding of VCD and have a worldwide impact on promoting better vascular cognitive outcomes.

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