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Successful reintroduction of tumour necrosis factor-alpha inhibition after treatment of disseminated Lyme borreliosis

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Original languageEnglish
Pages (from-to)122-124
Number of pages3
JournalJournal of the Royal College of Physicians of Edinburgh
Issue number2
Publication statusPublished - Jun 2019


The importance of tumour necrosis factor-alpha (TNF-α) in the human immune response to Borrelia burgdorferi is uncertain. Murine models suggest a critical role, including spirochaete reactivation following TNF-α inhibition. Our case, combined with a review of the clinical and scientific literature, provides reassurance that TNF-α inhibition can be safely reinstituted after treatment of disseminated borreliosis with standard duration antimicrobial chemotherapy.

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