Edinburgh Research Explorer

Suppression of avian influenza transmission in genetically modified chickens

Research output: Contribution to journalArticle

  • J. Lyall
  • R. M. Irvine
  • A. Sherman
  • T. J. McKinley
  • A. Nunez
  • A. Purdie
  • L. Outtrim
  • I. H. Brown
  • G. Rolleston-Smith
  • H. Sang
  • L. Tiley

Related Edinburgh Organisations

Original languageEnglish
Pages (from-to)223-226
Number of pages4
JournalScience
Volume331
Issue number6014
DOIs
StatePublished - Jan 2011

Abstract

Infection of chickens with avian influenza virus poses a global threat to both poultry production and human health that is not adequately controlled by vaccination or by biosecurity measures. A novel alternative strategy is to develop chickens that are genetically resistant to infection. We generated transgenic chickens expressing a short-hairpin RNA designed to function as a decoy that inhibits and blocks influenza virus polymerase and hence interferes with virus propagation. Susceptibility to primary challenge with highly pathogenic avian influenza virus and onward transmission dynamics were determined. Although the transgenic birds succumbed to the initial experimental challenge, onward transmission to both transgenic and nontransgenic birds was prevented.

ID: 37179