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Synthesis and cellular uptake of cell delivering PNA-peptide conjugates

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Original languageEnglish
Pages (from-to)3316-3318
Number of pages3
JournalChemical Communications
Issue number26
DOIs
Publication statusPublished - 2005

Abstract

The synthesis and cellular uptake of fluorescently labelled PNA-peptide conjugates is described; Dde/Mmt protected PNA monomers, fully orthogonal to Fmoc chemistry, were used to develop a flexible strategy to give Peptide Nucleic Acids conjugated to tri- and hepta-arginine and the short basic Tat(48-57) peptide as examples of cellular penetrating peptides, thereby allowing efficient cellular delivery of PNA into cells.

    Research areas

  • MEMBRANE-PERMEABLE PEPTIDES, DDE, DNA

ID: 1514367