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Synthesis and optimization of a reactive oxygen species responsive cellular delivery system

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http://xlink.rsc.org/?DOI=C6NJ02985J
Original languageEnglish
Pages (from-to)2392-2400
JournalNew journal of chemistry
Volume41
Issue number6
Early online date1 Feb 2017
DOIs
Publication statusE-pub ahead of print - 1 Feb 2017

Abstract

Reactive oxygen species play numerous roles in a number of pathological processes. Monitoring H2O2 is a powerful tool for imaging and therapy of diseases wherein oxidative stress is involved. In particular, we report a specific application of functional microspheres as sensors of H2O2. Reactive oxygen species responsive delivery systems were developed to detect in vitro peroxides thanks to the presence of a boronic ester which is readily cleaved with H2O2. This ROS-sensitive cleavable linker underwent a 1,6-elimination to disrupt fluorescence resonance energy transfer by coupled near-infrared fluorophores such as Cy5.5/Cy7. This technology would allow real-time monitoring of therapeutic regimes (and their success), as well as optical detection of inflammation.

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