Edinburgh Research Explorer

Systematic Review and Meta-Analysis of Haemostatic and Biliostatic Efficacy of Fibrin Sealants in Elective Liver Surgery

Research output: Contribution to journalArticle

Related Edinburgh Organisations

Original languageEnglish
JournalJournal of Gastrointestinal Surgery
Issue number4
Publication statusPublished - Apr 2013


BACKGROUND: Fibrin sealants are frequently used in liver surgery to achieve intraoperative haemostasis and reduce post-operative haemorrhage and bile leak. This meta-analysis aimed to review the haemostatic and biliostatic capacity of fibrin sealants in elective liver surgery. METHODS: An electronic search was performed on the MEDLINE, Embase and PubMed databases using both subject headings and truncated word searches to identify all published articles that are related to this topic. Pooled risk ratios were calculated for categorical outcomes, and mean differences for secondary continuous outcomes, using the fixed-effects and random-effects models for meta-analysis. RESULTS: Ten randomised controlled trials encompassing 1,225 patients were analysed to achieve a summated outcome. Pooled data analysis showed the use of fibrin sealants resulted in reduced time to haemostasis (mean difference -3.45 min [-3.78, -3.13] (P 

ID: 4931719