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Systematic review and meta-analysis of therapeutic hypothermia in animal models of spinal cord injury

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    Rights statement: Copyright: © 2013 Batchelor et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0071317
Original languageEnglish
Pages (from-to)e71317
JournalPLoS ONE
Volume8
Issue number8
DOIs
Publication statusPublished - 2013

Abstract

Therapeutic hypothermia is a clinically useful neuroprotective therapy for cardiac arrest and neonatal hypoxic ischemic encephalopathy and may potentially be useful for the treatment of other neurological conditions including traumatic spinal cord injury (SCI). The pre-clinical studies evaluating the effectiveness of hypothermia in acute SCI broadly utilise either systemic hypothermia or cooling regional to the site of injury. The literature has not been uniformly positive with conflicting studies of varying quality, some performed decades previously.

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