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Tailing off: PABP and CNOT generate cycles of mRNA deadenylation

Research output: Contribution to journalShort survey

Original languageEnglish
Pages (from-to)987-988
Number of pages2
JournalMolecular Cell
Volume70
Issue number6
DOIs
Publication statusE-pub ahead of print - 21 Jun 2018

Abstract

In this issue of Molecular Cell, Webster et al. (2018) and Yi et al. (2018) dissect the mechanisms underlying cytoplasmic mRNA deadenylation by the Ccr4-Not (CNOT) complex. Crucial to this process is the poly(A) binding protein Pab1/PABPC1, which both stimulates and suppresses the activity of different deadenylases. In this issue of Molecular Cell, Webster et al. (2018) and Yi et al. (2018) dissect the mechanisms underlying cytoplasmic mRNA deadenylation by the Ccr4-Not (CNOT) complex. Crucial to this process is the poly(A) binding protein Pab1/PABPC1, which both stimulates and suppresses the activity of different deadenylases.

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