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Tetrazine-Responsive Self-immolative Linkers

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http://doi.wiley.com/10.1002/cbic.201600560
Original languageEnglish
Pages (from-to)91-95
JournalChemBioChem
Volume18
Issue number1
DOIs
Publication statusPublished - 3 Jan 2017

Abstract

Molecules that undergo activation or modulation following the addition of benign external small-molecule chemical stimuli have numerous applications. Here, we report the highly efficient “decaging” of a variety of moieties by activation of a “self-immolative” linker, by application of water-soluble and stable tetrazine, including the controlled delivery of doxorubicin in a cellular context.

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