Edinburgh Research Explorer

The bone marrow functionally contributes to liver fibrosis

Research output: Contribution to journalArticle

  • Francesco P Russo
  • Malcolm R Alison
  • Brian W Bigger
  • Eunice Amofah
  • Aikaterini Florou
  • Farhana Amin
  • George Bou-Gharios
  • Rosemary Jeffery
  • John P Iredale
  • Stuart J Forbes

Related Edinburgh Organisations

Original languageEnglish
Pages (from-to)1807-21
Number of pages15
JournalGastroenterology
Volume130
Issue number6
DOIs
Publication statusPublished - May 2006

Abstract

Bone marrow (BM) cells may transdifferentiate into or fuse with organ parenchymal cells. BM therapy shows promise in murine models of cirrhosis, and clinical trials of bone marrow stem cell therapy for organ healing are underway. However, the BM may contribute to scar-forming myofibroblasts in various organs including the liver. We have studied this axis of regeneration and scarring in murine models of cirrhosis, including an assessment of the temporal and functional contribution of the BM-derived myofibroblasts.

    Research areas

  • Animals, Biopsy, Needle, Bone Marrow Transplantation, Disease Models, Animal, Disease Progression, Female, Immunohistochemistry, Liver Cirrhosis, Liver Regeneration, Male, Mice, Mice, Inbred BALB C, Photomicrography, Sensitivity and Specificity, Time Factors

ID: 4967569