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The chick as an animal model of eye disease

Research output: Contribution to journalArticle

Original languageEnglish
JournalDrug Discovery Today: Disease Models
VolumeE-pub 2 May
Early online date2 May 2014
DOIs
Publication statusPublished - 2014

Abstract

A diverse range of chicken lines harbouring highly-penetrant, spontaneously-occurring mutations with an ocular phenotype have been identified over the past 40 years. These lines serve as models for human monogenic disorders including ocular albinism, retinal dystrophies such as Leber's congenital amaurosis, and coloboma, as well as the common complex traits glaucoma and myopia. Recent technical advances in gene targeting, mapping quantitative trait loci, and phenotypic characterisation of eye phenotypes offer exciting prospects for exploiting chicken genomic resources in fundamental and translational eye research.

ID: 15287774