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The contributions of interlocking loops and extensive nonlinearity to the properties of circadian clock models

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Original languageEnglish
Article numbere13867
Number of pages11
JournalPLoS ONE
Volume5
Issue number11
DOIs
Publication statusPublished - Nov 2010

Abstract

Sensitivity and robustness are essential properties of circadian clock systems, enabling them to respond to the environment but resist noisy variations. These properties should be recapitulated in computational models of the circadian clock. Highly nonlinear kinetics and multiple loops are often incorporated into models to match experimental time-series data, but these also impact on model properties for clock models.

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