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The development of an online database for interventions tested in transgenic mouse models of Alzheimer's disease: Database on interventions for Alzheimer's disease

Research output: Contribution to journalArticle

Original languageEnglish
Pages (from-to)20-26
JournalEvidence-based Preclinical Medicine
Volume2
Issue number1
DOIs
Publication statusPublished - 1 Aug 2015

Abstract

Despite many efforts by the research community, Alzheimer's disease (AD) is still an incurable neurodegenerative condition that affects an estimated 44 million individuals worldwide and this figure is expected to increase to 135 million by the year 2050. As the research community currently reflects on previous endeavours, it is essential that we maximize the use of existing knowledge to inform future trials in the field. This article describes the development of a systematically identified data set relating to over 300 interventions tested in over 10,000 animals. The data set includes cohort-level information for six structural outcomes and six behavioural assessments. We encourage others to use this dataset to inform the design of future animal experiments modelling AD and to promote effective translation to human health.

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