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The developmental mutant talpid 3 lacks primary cilia

Research output: Contribution to journalMeeting abstract

  • F. Bangs
  • Y.L. Yin
  • R. Paton
  • A. Prescott
  • J. James
  • M. Davey
  • P. Whitley
  • G. Genikhovich
  • U. Technau
  • J. Briscoe
  • D. Burt
  • C. Tickle

Related Edinburgh Organisations

Original languageUndefined/Unknown
Pages (from-to)S262, abstract 16-P0002
JournalMechanisms of Ageing and Development
Volume126
Issue numberSupplement 1
DOIs
Publication statusPublished - 2009
Event16th International Society of Developmental Biologists Congress 2009 - Edinburgh, United Kingdom
Duration: 6 Sep 200910 Sep 2009

Abstract

The chicken talpid 3 mutant, with polydactyly and defects in other embryonic regions which depend on hedgehog (Hh) signalling, has a mutation in KIAA0586 . We have shown that cells of talpid 3 mutant embryos lack primary cilia and that the Talpid3 protein is localised to the centrosome. We have identified a highly conserved region of the Talpid3 protein, which is required to rescue primary cilia formation in talpid 3 mutant embryos and is sufficient for centrosomal localisation. Recently we have generated a transgenic mouse in which this highly conserved region is flanked with LoxP sites. We are now analysing the developmental consequences of deleting this conserved region of the gene either throughout the entire mouse embryo or in the limb.

Event

16th International Society of Developmental Biologists Congress 2009

6/09/0910/09/09

Edinburgh, United Kingdom

Event: Conference

ID: 268362