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The discovery of potent and selective kynurenine 3-monooxygenase inhibitors for the treatment of acute pancreatitis

Research output: Contribution to journalArticle

  • John Liddle
  • Benjamin Beaufils
  • Margaret Binnie
  • Anne Bouillot
  • Alexis A Denis
  • Michael M Hann
  • Carl P Haslam
  • Duncan S Holmes
  • Jon P Hutchinson
  • Michael Kranz
  • Andrew McBride
  • Olivier Mirguet
  • Damian J Mole
  • Christopher G Mowat
  • Sandeep Pal
  • Paul Rowland
  • Lionel Trottet
  • Iain J Uings
  • Ann L Walker
  • Scott P Webster

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Original languageEnglish
JournalBioorganic & Medicinal Chemistry Letters
Volume27
Issue number9
Early online date9 Mar 2017
DOIs
Publication statusPublished - May 2017

Abstract

A series of potent, competitive and highly selective kynurenine monooxygenase inhibitors have been discovered via a substrate-based approach for the treatment of acute pancreatitis. The lead compound demonstrated good cellular potency and clear pharmacodynamic activity in vivo.

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