Edinburgh Research Explorer

The diverse roles of mononuclear phagocytes in prion disease pathogenesis

Research output: Contribution to journalArticle

Related Edinburgh Organisations

Open Access permissions

Open

Documents

  • Download as Adobe PDF

    Rights statement: 2012 Landes Bioscience

    Final published version, 1.08 MB, PDF document

http://www.landesbioscience.com/journals/prion/article/18853/
Original languageEnglish
Pages (from-to)124-133
JournalPrion
Volume6
Issue number2
DOIs
Publication statusPublished - 2012
EventPrion 2011 - Montreal, Canada
Duration: 16 May 201119 May 2011

Abstract

Transmissible spongiform encephalopathies (TSEs), or prion diseases, are neurological diseases that can be transmitted through a number of different routes. A wide range of mammalian species are affected by the disease. After peripheral exposure, some TSE agents accumulate in lymphoid tissues at an early stage of disease prior to spreading to the nerves and the brain. Much research has focused on identifying the cells and molecules involved in the transmission of TSE agents from the site of exposure to the brain and several crucial cell types have been associated with this process. The identification of the key cells that influence the different stages of disease transmission might identify targets for therapeutic intervention. This review highlights the involvement of mononuclear phagocytes in TSE disease. Current data suggest these cells may exhibit a diverse range of roles in TSE disease from the transport or destruction of TSE agents in lymphoid tissues, to mediators or protectors of neuropathology in the brain.

Event

Prion 2011

16/05/1119/05/11

Montreal, Canada

Event: Conference

Download statistics

No data available

ID: 2568839