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The early phase transcriptome of bovine monocyte-derived macrophages infected with Staphylococcus aureus in vitro

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    Rights statement: © 2013 Lewandowska-Sabat et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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http://www.biomedcentral.com/1471-2164/14/891
Original languageEnglish
Article number891
Number of pages15
JournalBMC Genomics
Volume14
Issue number1
DOIs
Publication statusPublished - 17 Dec 2013

Abstract

In the mammary gland, local recruitment and action of macrophages is a key immunological defence mechanism against infection. Macrophages are members of the innate immune system, serve as the first line of the defence against invading pathogens and are critical effectors and regulators of inflammation. We have examined the early phase response of bovine macrophages to infection with live Staphylococcus aureus. Genome-wide transcript profiling of blood monocyte-derived macrophages from six Norwegian Red heifers infected with live S. aureus for 2 and 6 hours in vitro was performed.

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