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The effects of uterine artery embolisation and surgical treatment on ovarian function in women with uterine fibroids

Research output: Contribution to journalArticle

  • S. Rashid
  • A. Khaund
  • L. S. Murray
  • J. G. Moss
  • K. Cooper
  • D. Lyons
  • G. D. Murray
  • M. A. Lumsden

Related Edinburgh Organisations

Original languageEnglish
Pages (from-to)985-989
Number of pages5
JournalBJOG: An International Journal of Obstetrics and Gynaecology
Issue number8
Publication statusPublished - Jul 2010



The aim of this study was to evaluate and compare both ovarian function and menstrual characteristics following uterine artery embolisation (UAE) and surgery.


Subgroup of women from a randomised controlled trial.


Gynaecology and radiology units in Scotland, UK.


Ninety-six women from the randomised controlled trial comparing embolisation with surgery as a treatment for fibroids (REST), which recruited 157 patients (106 UAE; 51 surgery).


Seventy-three women undergoing UAE and 23 women undergoing surgery (with ovarian conservation) had serum follicle-stimulating hormone (FSH) measurements taken on day 3 of the menstrual cycle prior to treatment, and at 6 and 12 months post-treatment. Data on menstrual cycle characteristics was also collected.

Main outcome measures

Ovarian failure, as defined by an FSH level of > 40 iu/l, and change in duration of menses and length of menstrual cycle.


There was no significant difference in the rate of ovarian failure at 12 months between UAE (11%) and surgical patients (18%) (P = 0.44). This finding was not influenced by age. The mean duration of menstrual flow decreased significantly, from baseline to 12 months, by 1.7 days (SD 3.8), (95% CI 0.8-2.6). There was no statistically significant change in mean cycle length at 12 months (0.7 days [SD 4.9]; 95% CI [-0.5, 1.9]).


There is no evidence for UAE accelerating a deterioration in ovarian function at 1 year, when compared with surgery. UAE is associated with a decrease in the duration of menstrual flow at 1 year.

    Research areas

  • fibroids , hysterectomy , leiomyomata , ovarian function , uterine artery embolisation

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