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The expectant brain: adapting for motherhood

Research output: Contribution to journalReview article

Original languageEnglish
Pages (from-to)11-25
Number of pages15
JournalNature Reviews Neuroscience
Volume9
Issue number1
DOIs
Publication statusPublished - Jan 2008

Abstract

A successful pregnancy requires multiple adaptations of the mother's physiology to optimize fetal growth and development, to protect the fetus from adverse programming, to provide impetus for timely parturition and to ensure that adequate maternal care is provided after parturition. Many of these adaptations are organized by the mother's brain, predominantly through changes in neuroendocrine systems, and these changes are primarily driven by the hormones of pregnancy. By contrast, adaptations in the mother's brain during lactation are maintained by external stimuli from the young. The changes in pregnancy are not necessarily innocuous: they may predispose the mother to post-partum mood disorders.

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