TY - JOUR
T1 - The fluidic resistance of an array of obstacles and a method for improving boundaries in Deterministic Lateral Displacement arrays
AU - Inglis, David
AU - Vernekar, Rohan
AU - Krüger, Timm
AU - Feng, Shilun
PY - 2020/2/17
Y1 - 2020/2/17
N2 - Deterministic Lateral Displacement (DLD) is a microfluidic method of separating particles by size. DLD relies on precise flow patterns to deliver highresolutionparticle separation. These patterns determine which particles are displacedlaterally, and which follow the flow direction. Prior research has demonstrated that the lateral array boundaries can be designed to improve the uniformity of the critical size and hence separation performance. A DLD device with an invariant critical size throughout is yet unknown. In this work we propose a 3D design approach. We first represent the flow through the DLD as a 2D lattice of resistors. This is used to determine the relative flow resistances at the boundaries that will deliver the correct flux patterns. We then use the Lattice Boltzmann Method to simulate fluid flow in a 3D unit cell of the DLD and measure the fluidic resistance for a range or typical dimensions. The results of this work are used to create a new equation for fluidic resistance as a function of post size, post height, and post spacing.We use this equation to determine array geometries that should have the appropriate resistances. We then design and simulate (in COMSOL) complete devices and measure fluid fluxes and first flow-lane widths along the boundaries. We find that the first flow-lane widths are much more uniform than in any devices described previously. This work providesthe best method for designing periodic boundaries, and enables narrower, shorter and higher throughput DLD devices.
AB - Deterministic Lateral Displacement (DLD) is a microfluidic method of separating particles by size. DLD relies on precise flow patterns to deliver highresolutionparticle separation. These patterns determine which particles are displacedlaterally, and which follow the flow direction. Prior research has demonstrated that the lateral array boundaries can be designed to improve the uniformity of the critical size and hence separation performance. A DLD device with an invariant critical size throughout is yet unknown. In this work we propose a 3D design approach. We first represent the flow through the DLD as a 2D lattice of resistors. This is used to determine the relative flow resistances at the boundaries that will deliver the correct flux patterns. We then use the Lattice Boltzmann Method to simulate fluid flow in a 3D unit cell of the DLD and measure the fluidic resistance for a range or typical dimensions. The results of this work are used to create a new equation for fluidic resistance as a function of post size, post height, and post spacing.We use this equation to determine array geometries that should have the appropriate resistances. We then design and simulate (in COMSOL) complete devices and measure fluid fluxes and first flow-lane widths along the boundaries. We find that the first flow-lane widths are much more uniform than in any devices described previously. This work providesthe best method for designing periodic boundaries, and enables narrower, shorter and higher throughput DLD devices.
U2 - 10.1007/s10404-020-2323-x
DO - 10.1007/s10404-020-2323-x
M3 - Article
VL - 24
JO - Microfluidics and Nanofluidics
JF - Microfluidics and Nanofluidics
SN - 1613-4982
M1 - 18
ER -