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The genome and transcriptome of Haemonchus contortus, a key model parasite for drug and vaccine discovery

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  • Roz Laing
  • T Kikuchi
  • A Martinelli
  • I Tsai
  • R Beech
  • E Redman
  • R Holroyd
  • D Bartley
  • H Beasley
  • C Britton
  • D Curran
  • E Devaney
  • A Gilabert
  • M Hunt
  • S Johnston
  • I Kryukov
  • K Li
  • A Morrison
  • A Reid
  • G Saunders
  • J Wasmuth
  • A Wolstenholm
  • Matthew Berriman
  • John Gilleard
  • James Cotton

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    Rights statement: © 2013 Laing et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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    Licence: Creative Commons: Attribution (CC-BY)

http://genomebiology.com/2013/14/8/R88
Original languageEnglish
Article numberR88
JournalGenome Biology
Volume14
Issue number8
DOIs
StatePublished - 28 Aug 2013

Abstract

The small ruminant parasite Haemonchus contortus is the most widely used parasitic nematode in drug discovery, vaccine development and anthelmintic resistance research. Its remarkable propensity to develop resistance threatens the viability of the sheep industry in many regions of the world and provides a cautionary example of the effect of mass drug administration to control parasitic nematodes. Its phylogenetic position makes it particularly well placed for comparison with the free-living nematode Caenorhabditis elegans and the most economically important parasites of livestock and humans.

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