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The Hierarchy of Transcriptional Activation: From Enhancer to Promoter

Research output: Contribution to journalLiterature review

Original languageEnglish
Pages (from-to)696-708
JournalTrends in Genetics
Volume31
Issue number12
DOIs
Publication statusPublished - 12 Dec 2015

Abstract

Regulatory elements (enhancers) that are remote from promoters play a critical role in the spatial, temporal, and physiological control of gene expression. Studies on specific loci, together with genome-wide approaches, suggest that there may be many common mechanisms involved in enhancer-promoter communication. Here, we discuss the multiprotein complexes that are recruited to enhancers and the hierarchy of events taking place between regulatory elements and promoters.

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