Edinburgh Research Explorer

The Interfollicular Epidermis of Adult Mouse Tail Comprises Two Distinct Cell Lineages that Are Differentially Regulated by Wnt, Edaradd, and Lrig1

Research output: Contribution to journalArticle

  • Céline Gomez
  • Wesley Chua
  • Ahmad Miremadi
  • Sven Quist
  • Denis Headon
  • Fiona m. Watt

Related Edinburgh Organisations

Open Access permissions

Open

Documents

  • Download as Adobe PDF

    Rights statement: Open Access funded by Medical Research Council License: http://creativecommons.org/licenses/by/3.0/

    Final published version, 3.54 MB, PDF document

http://www.sciencedirect.com/science/article/pii/S2213671113000076
Original languageEnglish
Pages (from-to)19-27
Number of pages9
JournalStem Cell Reports
Volume1
Issue number1
DOIs
Publication statusPublished - 4 Jun 2013

Abstract

CURRENT MODELS OF HOW MOUSE TAIL INTERFOLLICULAR EPIDERMIS (IFE) IS MAINTAINED OVERLOOK THE COEXISTENCE OF TWO DISTINCT TERMINAL DIFFERENTIATION PROGRAMS: parakeratotic (scale) and orthokeratotic (interscale). Lineage tracing and clonal analysis revealed that scale and interscale are maintained by unipotent cells in the underlying basal layer, with scale progenitors dividing more rapidly than interscale progenitors. Although scales are pigmented and precisely aligned with hair follicles, melanocytes and follicles were not necessary for scale differentiation. Epidermal Wnt signaling was required for scale enlargement during development and for postnatal maintenance of scale-interscale boundaries. Loss of Edaradd inhibited ventral scale formation, whereas loss of Lrig1 led to scale enlargement and fusion. In wild-type skin, Lrig1 was not expressed in IFE but was selectively upregulated in dermal fibroblasts underlying the interscale. We conclude that the different IFE differentiation compartments are maintained by distinct stem cell populations and are regulated by epidermal and dermal signals.

Download statistics

No data available

ID: 8692951