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The Multifaceted Role of Perivascular Macrophages in Tumors

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http://www.sciencedirect.com/science/article/pii/S1535610816302227
Original languageEnglish
Pages (from-to)18-25
JournalCancer cell
Volume30
Issue number1
DOIs
Publication statusPublished - 11 Jul 2016

Abstract

Evidence has emerged for macrophages in the perivascular niche of tumors regulating important processes like angiogenesis, key events in the metastatic cascade, the recruitment and activity of other tumor-promoting leukocytes and tumor responses to the frontline therapies, irradiation and chemotherapy. Understanding the mechanisms controlling the recruitment, retention and function of these cells could lead to major targets for new anti-cancer therapeutics.

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