Edinburgh Research Explorer

The NEMP family supports metazoan fertility and nuclear envelope stiffness

Research output: Contribution to journalArticle

  • Yonit Tsatskis
  • Robyn Rosenfeld
  • Joel D. Pearson
  • Curtis Boswell
  • Yi Qu
  • Kyunga Kim
  • Lacramioara Fabian
  • Ariz Mohammed
  • Xian Wang
  • Karen Krchma
  • Jun Wu
  • João Gonçalves
  • Didier Hodzic
  • Shu Wu
  • Daniel Potter
  • Laurence Pelletier
  • Wade H. Dunham
  • Anne-Claude Gingras
  • Yu Sun
  • Jin Meng
  • Dorothea Godt
  • Tim Schedl
  • Brian Ciruna
  • Kyunghee Choi
  • John R B Perry
  • Rod Bremner
  • Julie A. Brill
  • Andrea Jurisicova
  • Helen McNeill

Related Edinburgh Organisations

Open Access permissions



  • Download as Adobe PDF

    Final published version, 3.46 MB, PDF document

    Licence: Creative Commons: Attribution Non-Commercial (CC-BY-NC)

Original languageEnglish
Article numbereabb4591
JournalScience Advances
Publication statusPublished - 28 Aug 2020


Human Genome Wide Association Studies have linked SNPs in NEMP1 (Nuclear Envelope Membrane Protein 1) with early menopause (1,2), however it is unclear if NEMP1 has any role in fertility. We show that whole animal loss of NEMP1 homologs in Drosophila, C. elegans, zebrafish and mice lead to sterility or early loss of fertility. Loss of Nemp leads to nuclear shaping defects, most prominently in the germline. Biochemical, biophysical and genetic studies reveal NEMP proteins support the mechanical stiffness of the germline nuclear envelope via formation of a NEMP
EMERIN complex. These data indicate that the germline nuclear envelope has specialized mechanical properties, and that NEMP proteins play essential and conserved roles in fertility.

Download statistics

No data available

ID: 161613423