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The neuroendocrine stress hormone norepinephrine augments Escherichia coli O157 : H7-induced enteritis and adherence in a bovine ligated ileal loop model of infection

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  • I Vlisidou
  • M Lyte
  • P M van Diemen
  • P Hawes
  • P Monaghan
  • T S Wallis
  • M P Stevens

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    Rights statement: Copyright © 2004, American Society for Microbiology

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http://iai.asm.org/content/72/9/5446
Original languageEnglish
Pages (from-to)5446-5451
Number of pages6
JournalInfection and Immunity
Volume72
Issue number9
DOIs
Publication statusPublished - Sep 2004

Abstract

The role of the neuroendocrine environment in the pathogenesis of enteric bacterial infections is increasingly being recognized. Here we report that norepinephrine augments Escherichia coli O157:H7-induced intestinal inflammatory and secretory responses as well as bacterial adherence to intestinal mucosa in a bovine ligated ileal loop model of infection. Norepinephrine modulation of enteritis and adherence was dependent on the ability of E. coli O157:H7 to form attaching and effacing lesions.

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