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The quail as an avian model system: its genome provides insights into social behaviour, seasonal biology and infectious disease response.

Research output: Working paper

  • S Boitard
  • Angela F Danner
  • Heather L Forrest
  • David Gourichon
  • Jérôme Gros
  • L Gourichon
  • L Hillier
  • Thierry Jaffredo
  • H Khoury
  • C Leterrier
  • Andrew Loudon
  • AS Mason
  • F Minvielle
  • P. Minx
  • F. Pitel
  • J Patrick Seiler
  • T Shimmura
  • C Tomlinson
  • A. Vignal
  • Robert G. Webster
  • T Yoshimura
  • W. C. Warren

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Original languageEnglish
DOIs
Publication statusPublished - 13 Mar 2019

Publication series

NamebioRxiv

Abstract

The Japanese quail (Coturnix japonica) is a popular domestic poultry species and an increasingly significant model species in avian developmental, behavioural and disease research. We have produced a high-quality quail genome sequence, spanning 0.93 Gb assigned to 33 chromosomes. In terms of contiguity, assembly statistics, gene content and chromosomal organization, the quail genome shows high similarity to the chicken genome.We demonstrate the utility of this genome through three diverse applications. First, we identify selection signatures and candidate genes associated with social behaviour in the quail
genome, an important agricultural and domestication trait. Second, we investigate the effects and interaction of photoperiod and temperature on the transcriptome of the quail medial basal hypothalamus, revealing key mechanisms of photoperiodism. Finally, we investigate the
response of quail to H5N1 influenza infection. In quail lung, many critical immune genes and pathways were downregulated, and this may be key to the susceptibility of quail to H5N1.This genome will facilitate further research into diverse research questions using the quail as a model avian species.

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