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The regulation of vascular endothelial growth factor by hypoxia and prostaglandin F₂α during human endometrial repair

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http://jcem.endojournals.org/content/96/8/2475
Original languageEnglish
Pages (from-to)2475-83
Number of pages9
JournalJournal of Clinical Endocrinology & Metabolism
Volume96
Issue number8
DOIs
Publication statusPublished - 2011

Abstract

The human endometrium has an exceptional capacity for repeated repair after menses, but its regulation remains undefined. Premenstrually, progesterone levels fall and prostaglandin (PG) F₂α synthesis increases, causing spiral arteriole constriction. We hypothesized that progesterone withdrawal, PGF₂α, and hypoxia increase vascular endothelial growth factor (VEGF), an endometrial repair factor.

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