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The role of Peroxisome proliferator-activated receptor gamma (PPARG) in adipogenesis: applying knowledge from the fish aquaculture industry to biomedical research

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    Rights statement: Copyright © 2017 Wafer, Tandon and Minchin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Original languageEnglish
JournalFrontiers in Endocrinology
Publication statusPublished - 22 May 2017


The tropical freshwater zebrafish has recently emerged as a valuable model
organism for the study of adipose tissue biology and obesity-related disease. The strengths of the zebrafish model system are its wealth of genetic mutants, transgenic tools and amenability to high-resolution imaging of cell dynamics within live animals. However, zebrafish adipose research is at a nascent stage and many gaps exist in our understanding of zebrafish adipose physiology and metabolism. By contrast, adipose research within other, closely-related, teleost species has a rich and extensive history, owing to the economic importance of these fish as a food source. Here we compare and contrast knowledge on PPARG-mediated adipogenesis derived from both biomedical and aquaculture literatures. We first concentrate on the biomedical literature to; (i) briefly review PPARG-mediated adipogenesis in mammals, before (ii) reviewing Pparg mediated adipogenesis in zebrafish. Finally, we (iii) mine the aquaculture literature to
compare and contrast Pparg-mediated adipogenesis in aquaculturally-relevant teleosts. Our goal is to highlight evolutionary similarities and differences in adipose biology that will inform our understanding of the role of adipose tissue in obesity and related disease.

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