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The Salmonella Pathogenicity Island 2-Encoded Type III Secretion System Is Essential for the Survival of Salmonella enterica Serovar Typhimurium in Free-Living Amoebae

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  • Benjamin Bleasdale
  • Penelope J. Lott
  • Aparna Jagannathan
  • Mark P. Stevens
  • Richard J. Birtles
  • Paul Wigley

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http://aem.asm.org/content/75/6/1793
Original languageEnglish
Pages (from-to)1793-1795
Number of pages3
JournalApplied and Environmental Microbiology
Volume75
Issue number6
DOIs
Publication statusPublished - Mar 2009

Abstract

Free-living amoebae represent a potential reservoir and predator of Salmonella enterica. Through the use of type III secretion system (T3SS) mutants and analysis of transcription of selected T3SS genes, we demonstrated that the Salmonella pathogenicity island 2 is highly induced during S. enterica serovar Typhimurium infection of Acanthamoeba polyphaga and is essential for survival within amoebae.

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