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Tools for efficient high-throughput synthesis

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Original languageEnglish
Pages (from-to)459-464
Number of pages6
JournalDrug Discovery Today
Volume12
Issue number11-12
DOIs
Publication statusPublished - Jun 2007

Abstract

Here, we detail the major developments in methods and techniques that are applicable to high-throughput synthesis that have evolved over the past five years, with an emphasis on the combination of microwave-based synthesis with techniques such as polymer-assisted purification and immobilized reagents and catalysts. Other aspects, such as automation, miniaturization and flow-based synthesis, are also presented as approaches that can be used for the rapid discovery and optimization of small organic molecules.

    Research areas

  • POLYMER-SUPPORTED REAGENTS, PHASE PEPTIDE-SYNTHESIS, FLOW ORGANIC-SYNTHESIS, DRUG DISCOVERY, COMPOUND LIBRARIES, TAGGED REAGENTS, MICROWAVE-OVENS, MICROREACTORS, PURIFICATION, SCAVENGERS

ID: 1512886