Edinburgh Research Explorer

Transgenic sheep designed for transplantation studies

Research output: Contribution to journalArticle

Original languageEnglish
Pages (from-to)61-64
Number of pages4
JournalMolecular Reproduction and Development
Volume76
Issue number1
DOIs
StatePublished - Jan 2009

Abstract

Lentiviral vectors have recently emerged as an efficient method of transgene delivery to the germline of animals. We now demonstrate that combining this efficiency with embryo splitting procedures enables the production of monozygotic twins, one of which is transgenic. We propose that this approach can be used to generate animals in which cell or tissue transplantation can be achieved without the use of immunosuppressive regimes.

    Research areas

  • cell therapies , embryology , monozygotic, ovine, transgene

ID: 69081